Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli
Identifieur interne : 001193 ( Main/Exploration ); précédent : 001192; suivant : 001194Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli
Auteurs : Po-Chun Chang [Singapour] ; Yang-Jo Seol [Corée du Sud] ; Steven A. Goldstein [États-Unis] ; William V. Giannobile [États-Unis]Source :
- The International journal of oral & maxillofacial implants [ 0882-2786 ] ; 2013.
Abstract
It is currently a challenge to determine the biomechanical properties of the hard tissue–dental implant interface. Recent advances in intraoral imaging and tomographic methods, such as microcomputed tomography (micro-CT), provide three-dimensional details, offering significant potential to evaluate the bone-implant interface, but yield limited information regarding osseointegration because of physical scattering effects emanating from metallic implant surfaces. In the present study, it was hypothesized that functional apparent moduli (FAM), generated from functional incorporation of the peri-implant structure, would eliminate the radiographic artifact–affected layer and serve as a feasible means to evaluate the biomechanical dynamics of tissue-implant integration in vivo.
Cylindric titanium mini-implants were placed in osteotomies and osteotomies with defects in rodent maxillae. The layers affected by radiographic artifacts were identified, and the pattern of tissue-implant integration was evaluated from histology and micro-CT images over a 21-day observation period. Analyses of structural information, FAM, and the relationship between FAM and interfacial stiffness (IS) were done before and after eliminating artifacts.
Physical artifacts were present within a zone of about 100 to 150 μm around the implant in both experimental defect situations (osteotomy alone and osteotomy + defect). All correlations were evaluated before and after eliminating the artifact-affected layers, most notably during the maturation period of osseointegration. A strong correlation existed between functional bone apparent modulus and IS within 300 μm at the osteotomy defects (r > 0.9) and functional composite tissue apparent modulus in the osteotomy defects (r > 0.75).
Micro-CT imaging and FAM were of value in measuring the temporal process of tissue-implant integration in vivo. This approach will be useful to complement imaging technologies for longitudinal monitoring of osseointegration.
Url:
PubMed: 23377049
PubMed Central: 4111564
Affiliations:
- Corée du Sud, Singapour, États-Unis
- Michigan, Région capitale de Séoul
- Séoul
- Université nationale de Singapour
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000420
- to stream Pmc, to step Curation: 000420
- to stream Pmc, to step Checkpoint: 000677
- to stream Ncbi, to step Merge: 000125
- to stream Ncbi, to step Curation: 000125
- to stream Ncbi, to step Checkpoint: 000125
- to stream Main, to step Merge: 001198
- to stream Main, to step Curation: 001193
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli</title><author><name sortKey="Chang, Po Chun" sort="Chang, Po Chun" uniqKey="Chang P" first="Po-Chun" last="Chang">Po-Chun Chang</name><affiliation wicri:level="4"><nlm:aff id="A1">Researcher, Department of Periodontics and Oral Medicine, School of Dentistry; Researcher, Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Assistant Professor, Discipline of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Researcher, Department of Periodontics and Oral Medicine, School of Dentistry; Researcher, Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Assistant Professor, Discipline of Periodontics, Faculty of Dentistry, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Seol, Yang Jo" sort="Seol, Yang Jo" uniqKey="Seol Y" first="Yang-Jo" last="Seol">Yang-Jo Seol</name><affiliation wicri:level="3"><nlm:aff id="A2">Researcher, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Associate Professor, Department of Periodontology, School of Dentistry, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Researcher, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Associate Professor, Department of Periodontology, School of Dentistry, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Goldstein, Steven A" sort="Goldstein, Steven A" uniqKey="Goldstein S" first="Steven A." last="Goldstein">Steven A. Goldstein</name><affiliation wicri:level="2"><nlm:aff id="A3">Professor, Department of Biomedical Engineering, College of Engineering; Professor, Department of Orthopedic Surgery, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Professor, Department of Biomedical Engineering, College of Engineering; Professor, Department of Orthopedic Surgery, School of Medicine, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Giannobile, William V" sort="Giannobile, William V" uniqKey="Giannobile W" first="William V." last="Giannobile">William V. Giannobile</name><affiliation wicri:level="2"><nlm:aff id="A4">Professor, Department of Periodontics and Oral Medicine, School of Dentistry; Professor, Department of Biomedical Engineering, College of Engineering; Director, Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Professor, Department of Periodontics and Oral Medicine, School of Dentistry; Professor, Department of Biomedical Engineering, College of Engineering; Director, Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23377049</idno><idno type="pmc">4111564</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111564</idno><idno type="RBID">PMC:4111564</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000420</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000420</idno><idno type="wicri:Area/Pmc/Curation">000420</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000420</idno><idno type="wicri:Area/Pmc/Checkpoint">000677</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000677</idno><idno type="wicri:Area/Ncbi/Merge">000125</idno><idno type="wicri:Area/Ncbi/Curation">000125</idno><idno type="wicri:Area/Ncbi/Checkpoint">000125</idno><idno type="wicri:doubleKey">0882-2786:2013:Chang P:determination:of:the</idno><idno type="wicri:Area/Main/Merge">001198</idno><idno type="wicri:Area/Main/Curation">001193</idno><idno type="wicri:Area/Main/Exploration">001193</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli</title><author><name sortKey="Chang, Po Chun" sort="Chang, Po Chun" uniqKey="Chang P" first="Po-Chun" last="Chang">Po-Chun Chang</name><affiliation wicri:level="4"><nlm:aff id="A1">Researcher, Department of Periodontics and Oral Medicine, School of Dentistry; Researcher, Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Assistant Professor, Discipline of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Researcher, Department of Periodontics and Oral Medicine, School of Dentistry; Researcher, Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Assistant Professor, Discipline of Periodontics, Faculty of Dentistry, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Seol, Yang Jo" sort="Seol, Yang Jo" uniqKey="Seol Y" first="Yang-Jo" last="Seol">Yang-Jo Seol</name><affiliation wicri:level="3"><nlm:aff id="A2">Researcher, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Associate Professor, Department of Periodontology, School of Dentistry, Seoul National University, Seoul, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Researcher, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA; Current Position, Associate Professor, Department of Periodontology, School of Dentistry, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Goldstein, Steven A" sort="Goldstein, Steven A" uniqKey="Goldstein S" first="Steven A." last="Goldstein">Steven A. Goldstein</name><affiliation wicri:level="2"><nlm:aff id="A3">Professor, Department of Biomedical Engineering, College of Engineering; Professor, Department of Orthopedic Surgery, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Professor, Department of Biomedical Engineering, College of Engineering; Professor, Department of Orthopedic Surgery, School of Medicine, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Giannobile, William V" sort="Giannobile, William V" uniqKey="Giannobile W" first="William V." last="Giannobile">William V. Giannobile</name><affiliation wicri:level="2"><nlm:aff id="A4">Professor, Department of Periodontics and Oral Medicine, School of Dentistry; Professor, Department of Biomedical Engineering, College of Engineering; Director, Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Professor, Department of Periodontics and Oral Medicine, School of Dentistry; Professor, Department of Biomedical Engineering, College of Engineering; Director, Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><series><title level="j">The International journal of oral & maxillofacial implants</title><idno type="ISSN">0882-2786</idno><idno type="eISSN">1942-4434</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">It is currently a challenge to determine the biomechanical properties of the hard tissue–dental implant interface. Recent advances in intraoral imaging and tomographic methods, such as microcomputed tomography (micro-CT), provide three-dimensional details, offering significant potential to evaluate the bone-implant interface, but yield limited information regarding osseointegration because of physical scattering effects emanating from metallic implant surfaces. In the present study, it was hypothesized that functional apparent moduli (FAM), generated from functional incorporation of the peri-implant structure, would eliminate the radiographic artifact–affected layer and serve as a feasible means to evaluate the biomechanical dynamics of tissue-implant integration in vivo.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">Cylindric titanium mini-implants were placed in osteotomies and osteotomies with defects in rodent maxillae. The layers affected by radiographic artifacts were identified, and the pattern of tissue-implant integration was evaluated from histology and micro-CT images over a 21-day observation period. Analyses of structural information, FAM, and the relationship between FAM and interfacial stiffness (IS) were done before and after eliminating artifacts.</p></sec><sec id="S3"><title>Results</title><p id="P3">Physical artifacts were present within a zone of about 100 to 150 μm around the implant in both experimental defect situations (osteotomy alone and osteotomy + defect). All correlations were evaluated before and after eliminating the artifact-affected layers, most notably during the maturation period of osseointegration. A strong correlation existed between functional bone apparent modulus and IS within 300 μm at the osteotomy defects (r > 0.9) and functional composite tissue apparent modulus in the osteotomy defects (r > 0.75).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Micro-CT imaging and FAM were of value in measuring the temporal process of tissue-implant integration in vivo. This approach will be useful to complement imaging technologies for longitudinal monitoring of osseointegration.</p></sec></div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Singapour</li><li>États-Unis</li></country><region><li>Michigan</li><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Chang, Po Chun" sort="Chang, Po Chun" uniqKey="Chang P" first="Po-Chun" last="Chang">Po-Chun Chang</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Seol, Yang Jo" sort="Seol, Yang Jo" uniqKey="Seol Y" first="Yang-Jo" last="Seol">Yang-Jo Seol</name></region></country><country name="États-Unis"><region name="Michigan"><name sortKey="Goldstein, Steven A" sort="Goldstein, Steven A" uniqKey="Goldstein S" first="Steven A." last="Goldstein">Steven A. Goldstein</name></region><name sortKey="Giannobile, William V" sort="Giannobile, William V" uniqKey="Giannobile W" first="William V." last="Giannobile">William V. Giannobile</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001193 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001193 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4111564
|texte= Determination of the Dynamics of Healing at the Tissue-Implant Interface by Means of Microcomputed Tomography and Functional Apparent Moduli
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23377049" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV1
| This area was generated with Dilib version V0.6.33. |  |